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Moreover, as the metabolic profile of the liberated parent drug (after cleavage of the derivative in the body) would be already known, it could be advantageous to design prodrug derivatives of par- ent compounds.
While the traditional prodrug approach was focused on altering various physiochemical parameters, the modern computational approach considers using a design of targeted prodrugs to certain enzymes or transporters or being inter- converted to their parent drugs without a metabolic activation process.
With the possibility of designing prodrugs with different linkers, the rate of release of the parent drug will be controlled and the drug's moiety, responsible for a bitter sensation, will be blocked (Karaman, 2014).
The parent drug, salicylic acid, is a weak reversible inhibitor of cyclooxygenase and thus cannot be considered a prodrug.
It was designed to have less abuse potential than other amphetamines due to the slower release of the active parent drug if inhaled or injected.
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